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Automatic determination of the pulse wave velocity in a body segment
Kampo, Dávid ; Svačinová, Jana (referee) ; Vondra, Vlastimil (advisor)
This Bachelor´s thesis deals with a propagation of a pulse wave velocity in different body segments and its measurement through bioimpedance. In connection with this topic, the work includes a profound description of a pulse wave and its velocity in regards to diagnostics and prevention of cardiovascular diseases that have been prevailing in recent years. During the process of determination of PWV, ECG is recorded, as it helps to accurately estimate the relevant transition times and the reulting PWV. The main purpose of this work is to validate that PWV can be determined without supportive ECG signals, what as a result makes the whole process simpler, more effective and available. The main target of this work has been successfully achieved and the algorithm for an evaluation of transition times and determination of PWV is described in the work. Moreover, the algorithm is implied to the structure of GUI in Matlab programm where the interface has been designed to suit the user´s needs to analyse PWV. Highlighting the validation process and functionality of the algorithm, signals from 21 subjects have been used to assess some of the most frequent analysed PWVs and all average values of velocities are within a physiological range from 5 m/s to 15 m/s. cfPWV is considered as a golden standard when it comes to PWV and the average value for all 21 subjects has been estimated to 7,54 m/s what corresponds with values from scientific studies that have been assessing cfPWV.
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Analysis of pulse wave propagation in aorta
Tichoň, Dušan ; Klas, Roman (referee) ; Burša, Jiří (advisor)
The aim of this diploma thesis is to assess the applicability of pulse wave propagation monitoring in the cardiovascular system in the field of prediction and early diagnosis of abdominal aortic aneurysm (AAA). The very first part is focused on description of heart and blood vessels with its pathological changes in presence of aneurysm. For this reason, current methods of monitoring and surgical treating of AAA were mentioned. Due to their difficult clinical use widely in the population, new methods based on pulse wave monitoring were presented. Using an analytical approach we estimated the difference in the arrival of the pulse wave at measurable locations between healthy and pathological aorta in the order of miliseconds. By experimental monitoring using photoplethysmographic sensors, we observed significant changes of pulse wave velocity with respect to the mechanical properties of the artery wall (mainly associated with age), which we tried to implement by hyperelastic material models used in computational simulations of pulse wave proagation on simplified geometries by fluid structure interaction method. These analyzes should verify applicability of FSI simulations in further development of diagnostic methods of AAA.
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Automatic determination of the pulse wave velocity in a body segment
Kampo, Dávid ; Svačinová, Jana (referee) ; Vondra, Vlastimil (advisor)
This Bachelor´s thesis deals with a propagation of a pulse wave velocity in different body segments and its measurement through bioimpedance. In connection with this topic, the work includes a profound description of a pulse wave and its velocity in regards to diagnostics and prevention of cardiovascular diseases that have been prevailing in recent years. During the process of determination of PWV, ECG is recorded, as it helps to accurately estimate the relevant transition times and the reulting PWV. The main purpose of this work is to validate that PWV can be determined without supportive ECG signals, what as a result makes the whole process simpler, more effective and available. The main target of this work has been successfully achieved and the algorithm for an evaluation of transition times and determination of PWV is described in the work. Moreover, the algorithm is implied to the structure of GUI in Matlab programm where the interface has been designed to suit the user´s needs to analyse PWV. Highlighting the validation process and functionality of the algorithm, signals from 21 subjects have been used to assess some of the most frequent analysed PWVs and all average values of velocities are within a physiological range from 5 m/s to 15 m/s. cfPWV is considered as a golden standard when it comes to PWV and the average value for all 21 subjects has been estimated to 7,54 m/s what corresponds with values from scientific studies that have been assessing cfPWV.
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|
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Analysis of pulse wave propagation in aorta
Tichoň, Dušan ; Klas, Roman (referee) ; Burša, Jiří (advisor)
The aim of this diploma thesis is to assess the applicability of pulse wave propagation monitoring in the cardiovascular system in the field of prediction and early diagnosis of abdominal aortic aneurysm (AAA). The very first part is focused on description of heart and blood vessels with its pathological changes in presence of aneurysm. For this reason, current methods of monitoring and surgical treating of AAA were mentioned. Due to their difficult clinical use widely in the population, new methods based on pulse wave monitoring were presented. Using an analytical approach we estimated the difference in the arrival of the pulse wave at measurable locations between healthy and pathological aorta in the order of miliseconds. By experimental monitoring using photoplethysmographic sensors, we observed significant changes of pulse wave velocity with respect to the mechanical properties of the artery wall (mainly associated with age), which we tried to implement by hyperelastic material models used in computational simulations of pulse wave proagation on simplified geometries by fluid structure interaction method. These analyzes should verify applicability of FSI simulations in further development of diagnostic methods of AAA.
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